The DYRK2 Polyclonal Antibody (CAB7012) is a high-quality research tool developed by Assay Genie for studying DYRK2, a serine/threonine kinase involved in cell cycle regulation and cellular proliferation. This antibody is raised in rabbits and has been validated for use in Western blot applications, specifically for detecting and analyzing DYRK2 protein expression in human samples.DYRK2 plays a crucial role in regulating various cellular processes, including DNA damage response, adipogenesis, and neuronal development. Dysregulation of DYRK2 has been implicated in diseases such as cancer, neurodegenerative disorders, and diabetes, making it a promising target for therapeutic interventions.
By using the DYRK2 Polyclonal Antibody, researchers can gain insights into the function and regulation of DYRK2 in different cellular contexts, advancing our understanding of its role in health and disease.Overall, the DYRK2 Polyclonal Antibody is a valuable tool for researchers working in the fields of cell biology, cancer biology, and drug discovery, enabling them to investigate the molecular mechanisms involving DYRK2 and its potential as a therapeutic target.
Product Name:
DYRK2 Rabbit Polyclonal Antibody
SKU:
CAB7012
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 429-528 of human DYRK2 (NP_003574.1).
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
Purification Method:
Affinity purification
Gene ID:
8445
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DYRK2 antibody (CAB7012) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
