The DYRK2 Polyclonal Antibody is specifically designed for research involving DYRK2, a dual-specificity tyrosine phosphorylation-regulated kinase that plays a crucial role in cell cycle regulation, apoptosis, and DNA damage response. This antibody, produced in rabbits, exhibits high reactivity with human tissue samples and has been validated for use in Western blot applications. By binding to the DYRK2 protein, researchers can effectively detect and analyze DYRK2 expression in a wide range of cell types, making it a valuable tool for studies in cancer and cell biology research.DYRK2 is known for its involvement in the regulation of key cellular processes such as cell division and programmed cell death, making it a promising target for investigating diseases like cancer and neurodegenerative disorders.
Understanding the function of DYRK2 at the molecular level is crucial for gaining insights into disease mechanisms and developing potential therapeutic interventions that target this kinase. By utilizing the DYRK2 Polyclonal Antibody, researchers can further explore the role of DYRK2 in various cellular pathways and uncover its potential implications in disease pathology.
Product Name:
DYRK2 Polyclonal Antibody
SKU:
CAB24467
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human DYRK2.
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
Purification Method:
Affinity purification
Gene ID:
8445
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DYRK2 Rabbit pAb (CAB24467) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
