The DYRK1B Polyclonal Antibody (PACO05700) is specifically designed for research involving the DYRK1B protein, a member of the DYRK family of kinases that plays a critical role in various cellular processes including cell growth, proliferation, and differentiation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds specifically to the DYRK1B protein, allowing for accurate detection and analysis in a variety of cell types.DYRK1B is known to be involved in the regulation of cell cycle progression, cell survival, and gene expression, making it a promising target for studies in areas such as cancer research, developmental biology, and neurodegenerative diseases.
Understanding the function of DYRK1B is essential for elucidating its role in these processes and potentially identifying new therapeutic targets for related conditions.Overall, the DYRK1B Polyclonal Antibody is a valuable tool for researchers interested in investigating the function and potential therapeutic significance of the DYRK1B protein in various biological contexts.
Antibody Name:
DYRK1B Antibody (PACO05700)
Antibody SKU:
PACO05700
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the Internal region of human Dyrk1B.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding; protein kinase activity; transcription coactivator activityBiological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylationDisease: Abdominal Obesity-metabolic Syndrome 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
