DYRK1A Rabbit Polyclonal Antibody (CAB0595)
- SKU:
- CAB0595
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | DYRK1A Rabbit Polyclonal Antibody |
SKU: | CAB0595 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 624-763 of human DYRK1A (NP_001387.2). |
Sequence: | LGNR TRPR VYNS PTNS SSTQ DSME VGHS HHSM TSLS SSTT SSST SSSS TGNQ GNQA YQNR PVAA NTLD FGQN GAMD VNLT VYSN PRQE TGIA GHPT YQFS ANTG PAHY MTEG HLTM RQGA DREE SPMT GVCV QQSP VASS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | MNB; DYRK; HP86; MNBH; MRD7; DYRK1; DYRK1A |
Positive Sample: | 293T,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus speckle. |
Calculated MW: | 86kDa |
Observed MW: | 70kDa |
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 1859 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |