The DYNLL1 Polyclonal Antibody (CAB5742) is essential for research involving DYNLL1, a protein involved in various cellular functions, including intracellular transport and cell cycle regulation. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. DYNLL1, also known as dynein light chain 1, plays a crucial role in the interaction between dynein and cargo proteins, facilitating the transport of various cellular components. Its involvement in cellular processes makes it a key target for studies in cell biology, molecular biology, and neurobiology.
The DYNLL1 Polyclonal Antibody enables the detection and analysis of DYNLL1 protein in different cell types, allowing researchers to investigate its role in cellular functions and pathways. Understanding the functions of DYNLL1 is essential for advancing research in areas such as intracellular transport, cell division, and neuronal development. This antibody is a valuable tool for researchers exploring the diverse functions of DYNLL1 in various biological processes.
Product Name:
DYNLL1 Rabbit Polyclonal Antibody
SKU:
CAB5742
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human DYNLL1 (NP_003737.1).
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
Purification Method:
Affinity purification
Gene ID:
8655
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DYNLL1 antibody (CAB5742) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
