The DYNC2H1 Polyclonal Antibody (CAB13126) is a key tool for researchers studying the DYNC2H1 protein, a member of the dynein family involved in intraflagellar transport and cilia assembly. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting DYNC2H1 in human samples, making it an essential tool for immunohistochemistry and Western blot applications.DYNC2H1 is essential for proper cilia function and cellular movement, playing a crucial role in various developmental processes and cellular signaling pathways. Dysregulation of DYNC2H1 has been linked to ciliopathies and genetic disorders, making it a promising target for therapeutic interventions targeting cilia-related diseases.
By utilizing the DYNC2H1 Polyclonal Antibody, researchers can gain valuable insights into the localization, expression, and function of DYNC2H1 in different biological contexts, advancing our understanding of cilia biology and its implications for human health. This antibody is a valuable tool for studies in developmental biology, ciliopathies, and related fields, paving the way for the development of innovative treatments for cilia-related disorders.
Product Name:
DYNC2H1 Rabbit Polyclonal Antibody
SKU:
CAB13126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DYNC2H1 (NP_001073932.1).
This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Purification Method:
Affinity purification
Gene ID:
79659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat testis, using DYNC2H1 Rabbit pAb (CAB13126) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
