The Dynactin Subunit 1 Polyclonal Antibody (CAB14725) is a vital tool for researchers studying DYNC1I2, a key component in the dynein-dynactin motor complex that plays a critical role in intracellular transport processes. This antibody, produced in rabbits, is highly specific to human DYNC1I2 and has been validated for use in Western blot applications. By targeting the DYNC1I2 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studies in cell biology and neurodegenerative diseases.
DYNC1I2 is essential for the proper function of the dynein-dynactin complex, which is involved in transporting organelles, vesicles, and other cell components along microtubules. Dysregulation of this complex has been implicated in neurodegenerative disorders such as Alzheimer's and ALS. Studying the activity of DYNC1I2 is crucial for understanding the mechanisms underlying these diseases and developing potential therapeutic strategies to target intracellular transport defects.
Product Name:
DYNC1I2 Rabbit Polyclonal Antibody
SKU:
CAB14725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 352-612 of human DYNC1I2 (NP_001258717.1).
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DYNC1I2 Rabbit pAb (CAB14725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
