DCTN2 Rabbit Polyclonal Antibody (CAB2200)
- SKU:
- CAB2200
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | DCTN2 Rabbit Polyclonal Antibody |
SKU: | CAB2200 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-320 of human DCTN2 (NP_006391.1). |
Sequence: | HIIV NPNA AYDK FKDK RVGT KGLD FSDR IGKT KRTG YESG EYEM LGEG LGVK ETPQ QKYQ RLLH EVQE LTTE VEKI KTTV KESA TEEK LTPV LLAK QLAA LKQQ LVAS HLEK LLGP DAAI NLTD PDGA LAKR LLLQ LEAT KNSK GGSG GKTT GTPP DSSL VTYE LHSR PEQD KFSQ AAKV AELE KRLT ELET AVRC DQDA QNPL SAGL QGAC LMET VELL QAKV SALD LAVL DQVE ARLQ SVLG KVNE IAKH KASV EDAD TQSK VHQL YET |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:20 - 1:50 |
Synonyms: | RBP50; DCTN50; HEL-S-77; DYNAMITIN; DCTN2 |
Positive Sample: | MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center. |
Calculated MW: | 44kDa |
Observed MW: | 44kDa |
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 10540 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |