The DVL2 Polyclonal Antibody (CAB14726) is a valuable tool for researchers studying the DVL2 protein, which is involved in the Wnt signaling pathway, regulating cell proliferation, differentiation, and migration. This antibody, produced in rabbits, has been shown to exhibit high reactivity with human samples and is validated for use in Western blot applications.DVL2 is a key player in various cellular processes, including embryonic development, tissue regeneration, and oncogenesis. Dysregulation of the Wnt signaling pathway, in which DVL2 plays a pivotal role, has been implicated in various diseases, including cancer and developmental disorders.
By binding to the DVL2 protein, this antibody allows for the detection and analysis of DVL2 expression in different cell types, making it suitable for studies in developmental biology, cancer research, and drug discovery.Understanding the function and regulation of DVL2 is essential for deciphering the complex mechanisms underlying disease pathology and identifying potential therapeutic targets. The DVL2 Polyclonal Antibody (CAB14726) provides researchers with a reliable tool to investigate the role of DVL2 in cellular processes and disease progression, ultimately leading to new insights and advancements in biomedical research.
Product Name:
DVL2 Rabbit Polyclonal Antibody
SKU:
CAB14726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1).
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Purification Method:
Affinity purification
Gene ID:
1856
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using DVL2 antibody (CAB14726) at dilution of 1:100. Blue: DAPI for nuclear staining.
