The DVL1 Polyclonal Antibody (AB1001) is a specialized research tool designed for the detection and analysis of DVL1 protein, a key component in the Wnt signaling pathway. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.DVL1, also known as Dishevelled 1, plays a crucial role in cell signaling, particularly in the regulation of cell proliferation, differentiation, and migration. Dysregulation of the Wnt signaling pathway, in which DVL1 is a critical player, has been implicated in various diseases, including cancer and developmental disorders.
By enabling the detection and analysis of DVL1 protein in various cell types, the DVL1 Polyclonal Antibody is essential for research in molecular biology, cancer biology, and developmental biology. Understanding the function and regulation of DVL1 protein is paramount for unraveling the complexities of cell signaling pathways and their implications in disease pathogenesis.
Product Name:
DVL1 Polyclonal Antibody
SKU:
CAB24657
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 11-110 of human DVL1 (NP_001317240.1).
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Purification Method:
Affinity purification
Gene ID:
1855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using DVL1 Rabbit pAb (CAB24657) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
