The DVL1 Polyclonal Antibody (CAB10536) is a valuable tool for researchers studying DVL1, a key protein involved in the Wnt signaling pathway. This pathway plays a crucial role in various cellular processes, including cell growth, differentiation, and development. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the DVL1 protein, this antibody allows for the detection and analysis of DVL1 expression in different cell types, making it ideal for studies in cell biology and cancer research.
DVL1 is a critical mediator of Wnt signaling, which is dysregulated in various diseases, including cancer and developmental disorders. Understanding the role of DVL1 in these processes is essential for developing targeted therapies that can modulate Wnt signaling for therapeutic purposes.Overall, the DVL1 Polyclonal Antibody (CAB10536) provides researchers with a reliable tool to study the function of DVL1 and its implications in disease pathogenesis, paving the way for the development of novel therapeutic interventions.
Product Name:
DVL1 Rabbit Polyclonal Antibody
SKU:
CAB10536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 510-640 of human DVL1 (NP_004412.2).
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Purification Method:
Affinity purification
Gene ID:
1855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DVL1 Rabbit pAb (CAB10536) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
