DUSP9 Rabbit Polyclonal Antibody (CAB3839)
- SKU:
- CAB3839
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | DUSP9 Rabbit Polyclonal Antibody |
SKU: | CAB3839 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DUSP9 (NP_001386.1). |
Sequence: | MEGL GRSC LWLR RELS PPRP RLLL LDCR SREL YESA RIGG ALSV ALPA LLLR RLRR GSLS VRAL LPGP PLQP PPPA PVLL YDQG GGRR RRGE AEAE AEEW EAES VLGT LLQK LREE GYLA YYLQ GGFS RFQA ECPH LCET SLAG RAGS SMAP VPGP VPVV GLGS LCLG SDCS DAES EADR DSMS CGLD SEGA TPPP VGLR |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 IF/ICC,1:20 - 1:100 |
Synonyms: | MKP4; MKP-4; DUSP9 |
Positive Sample: | HeLa,HepG2,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 42kDa |
Observed MW: | 41kDa |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1852 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |