The DUSP6 Polyclonal Antibody (CAB3171) is a valuable tool for researchers studying the dual-specificity phosphatase 6 (DUSP6) protein. DUSP6 is a critical regulator of cellular signaling pathways, particularly those involved in cell growth and differentiation. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting DUSP6 in human samples.Validated for use in Western blot applications, this antibody enables precise detection and analysis of DUSP6 protein levels in various cell types. Its reliable performance makes it an ideal choice for studies in molecular biology, cell signaling, and cancer research.
DUSP6 has been implicated in multiple cellular processes, including cell proliferation, apoptosis, and response to environmental stresses. Dysregulation of DUSP6 expression has been linked to diseases such as cancer, diabetes, and neurodegenerative disorders. By targeting DUSP6 with this polyclonal antibody, researchers can gain valuable insights into the role of this protein in health and disease, paving the way for the development of novel therapeutic strategies.
Product Name:
DUSP6 Rabbit Polyclonal Antibody
SKU:
CAB3171
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence within amino acids 302-381 of human DUSP6 (NP_001937.2).
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DUSP6 Rabbit pAb (CAB3171) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
