The DUSP6 Rabbit Monoclonal Antibody is a specialized tool for researchers studying DUSP6, a dual-specificity phosphatase involved in regulating MAP kinase signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting DUSP6 in human samples, making it ideal for Western blot applications. By binding to the DUSP6 protein, researchers can accurately analyze and quantify its expression in various cell types.
The role of DUSP6 in cell signaling cascades makes it a key target for studies in cancer biology, developmental biology, and signal transduction mechanisms. Understanding the function of DUSP6 is essential for unraveling its contributions to disease development and progression, paving the way for potential therapeutic interventions targeting this pathway.
Product Name:
DUSP6 Rabbit Monoclonal Antibody
SKU:
CAB0133
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 282-381 of human DUSP6 (Q16828).
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1848
Clone Number:
ARC0237
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using DUSP6 Rabbit mAb (CAB0133) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
