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DUSP4 Rabbit Polyclonal Antibody (CAB2726)

SKU:
CAB2726
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:DUSP4 Rabbit Polyclonal Antibody
SKU:CAB2726
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4 (NP_001385.1).
Sequence:MVTM EELR EMDC SVLK RLMN RDEN GGGA GGSG SHGT LGLP SGGK CLLL DCRP FLAH SAGY ILGS VNVR CNTI VRRR AKGS VSLE QILP AEEE VRAR LRSG LYSA VIVY DERS PRAE SLRE DSTV SLVV QALR RNAE RTDI CLLK GGYE RFSS EYPE FCSK TKAL AAIP
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:TYP; HVH2; MKP2; MKP-2; DUSP4
Positive Sample:COS-7,HeLa,A375
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:43kDa
Observed MW:47kDa

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Purification Method:Affinity purification
Gene ID:1846
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using DUSP4 Rabbit pAb (CAB2726) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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