DUSP3 Rabbit Polyclonal Antibody (CAB12068)
- SKU:
- CAB12068
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | DUSP3 Rabbit Polyclonal Antibody |
SKU: | CAB12068 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DUSP3 (NP_004081.1). |
Sequence: | MSGS FELS VQDL NDLL SDGS GCYS LPSQ PCNE VTPR IYVG NASV AQDI PKLQ KLGI THVL NAAE GRSF MHVN TNAN FYKD SGIT YLGI KAND TQEF NLSA YFER AADF IDQA LAQK NGRV LVHC REGY SRSP TLVI AYLM MRQK MDVK SALS IVRQ NREI GPND GFLA QLCQ LNDR LAKE GKLK P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | VHR; DUSP3 |
Positive Sample: | Mouse stomach,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 20kDa |
Observed MW: | 20kDa |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Purification Method: | Affinity purification |
Gene ID: | 1845 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |