DUSP26 Antibody (PACO40490)
- SKU:
- PACO40490
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DUSP26 Antibody (PACO40490)
The DUSP26 Antibody (PAC040490) is a highly specific tool for researchers studying dual-specificity phosphatase 26, a key enzyme involved in regulating cellular signaling pathways. This polyclonal antibody, produced in rabbits, is ideal for detecting and quantifying DUSP26 protein levels in human samples, particularly in Western blot applications.Dual-specificity phosphatase 26, also known as MKP8, plays a crucial role in dephosphorylating and inactivating key signaling molecules, thus modulating cell proliferation, differentiation, and apoptosis. Dysregulation of DUSP26 has been linked to various diseases, including cancer, neurodegenerative disorders, and immune-related conditions.
By targeting DUSP26, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic targets.With its high specificity and sensitivity, the DUSP26 Antibody (PAC040490) is a valuable tool for studies in oncology, neurology, and immunology. Its ability to accurately detect DUSP26 protein levels makes it an essential reagent for researchers seeking to understand the role of this enzyme in health and disease.
| Antibody Name: | DUSP26 Antibody (PACO40490) |
| Antibody SKU: | PACO40490 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dual specificity protein phosphatase 26 protein (1-211AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO40490 at dilution of 1:100. |
 | Immunofluorescence staining of SH-SY5Y cells with PACO40490 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO40490 at dilution of 1:100. |
| Background: | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Synonyms: | Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer), DUSP26, DUSP24 LDP4 MKP8 NATA1 SKRP3 |
| UniProt Protein Function: | DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 8p12Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleusMolecular Function: protein binding; p53 binding; phosphoserine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activityBiological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q9BV47 |
| NCBI GenInfo Identifier: | 74752374 |
| NCBI Gene ID: | 78986 |
| NCBI Accession: | Q9BV47.1 |
| UniProt Secondary Accession: | Q9BV47,Q9BTW0, D3DSV8 |
| UniProt Related Accession: | Q9BV47 |
| Molecular Weight: | 23,946 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 26 |
| NCBI Synonym Full Names: | dual specificity phosphatase 26 (putative) |
| NCBI Official Symbol: | DUSP26Â Â |
| NCBI Official Synonym Symbols: | MKP8; LDP-4; NATA1; SKRP3; DUSP24Â Â |
| NCBI Protein Information: | dual specificity protein phosphatase 26; DSP-4; MKP-8; MAP kinase phosphatase 8; dual specificity phosphatase SKRP3; dual-specificity phosphatase SKRP3; mitogen-activated protein kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; low-molecular-mass dual-specificity phosphatase 4 |
| UniProt Protein Name: | Dual specificity protein phosphatase 26 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP26Â Â |
| UniProt Entry Name: | DUS26_HUMAN |
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