DUSP26 Antibody (PACO16211)
- SKU:
- PACO16211
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DUSP26 Antibody (PACO16211)
The DUSP26 Polyclonal Antibody (PAC016211) is a valuable tool for researchers studying the DUSP26 protein, a member of the dual-specificity phosphatase family involved in the regulation of cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically designed for use in Western blot applications. By binding to the DUSP26 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for research in molecular biology and cancer biology.
DUSP26, also known as MAP kinase phosphatase 8 (MKP-8), plays a key role in modulating the activity of MAP kinases, which are critical for cellular communication and response to external stimuli. Dysregulation of DUSP26 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By studying the function of DUSP26, researchers can gain insights into the mechanisms underlying disease progression and potentially develop novel treatment strategies targeting this phosphatase.
| Antibody Name: | DUSP26 Antibody (PACO16211) |
| Antibody SKU: | PACO16211 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DUSP26 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16211(DUSP26 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16211(DUSP26 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | DUSP26, also designated LDP4, MKP8, NATA1 and SKRP3, is ubiquitously expressed in brain except in the hippocampus. DUSP26 dephosphorylates p38 thereby inhibiting p38-mediated apoptosis in anaplastic thyroid cancer cells. Downregulation of DUSP26 may also contribute to malignant phenotypes of glioma. |
| Synonyms: | dual specificity phosphatase 26 (putative) |
| UniProt Protein Function: | DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 8p12Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleusMolecular Function: protein binding; p53 binding; phosphoserine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activityBiological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q9BV47 |
| NCBI GenInfo Identifier: | 74752374 |
| NCBI Gene ID: | 78986 |
| NCBI Accession: | Q9BV47.1 |
| UniProt Secondary Accession: | Q9BV47,Q9BTW0, D3DSV8 |
| UniProt Related Accession: | Q9BV47 |
| Molecular Weight: | 23,946 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 26 |
| NCBI Synonym Full Names: | dual specificity phosphatase 26 (putative) |
| NCBI Official Symbol: | DUSP26Â Â |
| NCBI Official Synonym Symbols: | MKP8; LDP-4; NATA1; SKRP3; DUSP24Â Â |
| NCBI Protein Information: | dual specificity protein phosphatase 26; DSP-4; MKP-8; MAP kinase phosphatase 8; dual specificity phosphatase SKRP3; dual-specificity phosphatase SKRP3; mitogen-activated protein kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; low-molecular-mass dual-specificity phosphatase 4 |
| UniProt Protein Name: | Dual specificity protein phosphatase 26 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP26Â Â |
| UniProt Entry Name: | DUS26_HUMAN |
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