Anti-DUSP26 Antibody (PACO16210)

Antibody Name:	DUSP26 Antibody (PACO16210)
Antibody SKU:	PACO16210
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human DUSP26

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16210(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16210(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).

Background:	DUSP26, also designated LDP4, MKP8, NATA1 and SKRP3, is ubiquitously expressed in brain except in the hippocampus. DUSP26 dephosphorylates p38 thereby inhibiting p38-mediated apoptosis in anaplastic thyroid cancer cells. Downregulation of DUSP26 may also contribute to malignant phenotypes of glioma.
Synonyms:	dual specificity phosphatase 26 (putative)

UniProt Protein Function:	DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 8p12Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleusMolecular Function: protein binding; p53 binding; phosphoserine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activityBiological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Code:	Q9BV47
NCBI GenInfo Identifier:	74752374
NCBI Gene ID:	78986
NCBI Accession:	Q9BV47.1
UniProt Secondary Accession:	Q9BV47,Q9BTW0, D3DSV8
UniProt Related Accession:	Q9BV47
Molecular Weight:	23,946 Da
NCBI Full Name:	Dual specificity protein phosphatase 26
NCBI Synonym Full Names:	dual specificity phosphatase 26 (putative)
NCBI Official Symbol:	DUSP26
NCBI Official Synonym Symbols:	MKP8; LDP-4; NATA1; SKRP3; DUSP24
NCBI Protein Information:	dual specificity protein phosphatase 26; DSP-4; MKP-8; MAP kinase phosphatase 8; dual specificity phosphatase SKRP3; dual-specificity phosphatase SKRP3; mitogen-activated protein kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; low-molecular-mass dual-specificity phosphatase 4
UniProt Protein Name:	Dual specificity protein phosphatase 26
UniProt Synonym Protein Names:	Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer
Protein Family:	Dual specificity protein phosphatase
UniProt Gene Name:	DUSP26
UniProt Entry Name:	DUS26_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)