The DUSP26 Polyclonal Antibody (PAC016210) is a valuable tool for researchers studying the DUSP26 protein, a phosphatase involved in regulating MAPK signaling pathways and cell growth. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DUSP26 protein, this antibody allows for the detection and analysis of DUSP26 expression in various cell types, making it an essential component of studies in cancer biology, cell signaling, and drug development.DUSP26, also known as dual specificity phosphatase 26, is a key player in the MAPK signaling cascade, which controls cellular processes such as proliferation, differentiation, and apoptosis.
Dysregulation of DUSP26 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Research into the function and regulation of DUSP26 is crucial for uncovering new treatment strategies and improving our understanding of disease mechanisms.Overall, the DUSP26 Polyclonal Antibody (PAC016210) is a reliable tool for investigating the role of DUSP26 in health and disease, providing valuable insights into cellular signaling pathways and potential therapeutic targets.
Antibody Name:
DUSP26 Antibody (PACO16210)
Antibody SKU:
PACO16210
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human DUSP26
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16210(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16210(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
DUSP26, also designated LDP4, MKP8, NATA1 and SKRP3, is ubiquitously expressed in brain except in the hippocampus. DUSP26 dephosphorylates p38 thereby inhibiting p38-mediated apoptosis in anaplastic thyroid cancer cells. Downregulation of DUSP26 may also contribute to malignant phenotypes of glioma.
Synonyms:
dual specificity phosphatase 26 (putative)
UniProt Protein Function:
DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 8p12Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleusMolecular Function: protein binding; p53 binding; phosphoserine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activityBiological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
