The DUSP16 Polyclonal Antibody (PAC023280) is a valuable tool for researchers studying the dual-specificity phosphatase 16 (DUSP16) protein. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By binding specifically to DUSP16, this antibody enables precise detection and analysis of the protein in various cell types.DUSP16 is a phosphatase enzyme that plays a vital role in the regulation of cellular signaling pathways, particularly those involved in immune responses and cell growth.
Dysregulation of DUSP16 has been implicated in various diseases, including cancer and inflammatory disorders. As such, elucidating the function and regulation of DUSP16 is essential for developing targeted therapies for these conditions.With its specificity and reliability, the DUSP16 Polyclonal Antibody (PAC023280) offers a valuable tool for researchers seeking to expand their understanding of DUSP16 biology and its implications for human health. Its versatility and sensitivity make it a valuable asset for studies in immunology, oncology, and beyond.
Synthesized peptide derived from internal of human DUSP16.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells and COLO205 cells, using DUSP16 antibody.
Immunofluorescence analysis of HepG2 cells, using DUSP16 antibody.
Background:
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
Synonyms:
Dual specificity protein phosphatase 16; EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7
UniProt Protein Function:
NPM1 iso3: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.Protein type: Oncoprotein; Translation; Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 5q35.1Cellular Component: nucleoplasm; centrosome; focal adhesion; membrane; cytoplasm; nucleolus; spindle pole centrosome; nucleus; ribonucleoprotein complex; cytosolMolecular Function: protein homodimerization activity; protein kinase inhibitor activity; histone binding; RNA binding; unfolded protein binding; transcription coactivator activity; protein kinase binding; ribosomal large subunit binding; NF-kappaB binding; protein binding; Tat protein binding; protein heterodimerization activity; ribosomal small subunit bindingBiological Process: regulation of centriole replication; viral reproduction; positive regulation of translation; centrosome cycle; cell aging; nucleocytoplasmic transport; signal transduction; DNA repair; protein oligomerization; activation of NF-kappaB transcription factor; intracellular protein transport; nucleosome assembly; negative regulation of cell proliferation; protein localization; regulation of endodeoxyribonuclease activity; DNA replication-independent nucleosome assembly at centromere; ribosome assembly; response to stress; negative regulation of apoptosis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
