DUSP13 Antibody (PACO08953)
- SKU:
- PACO08953
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
DUSP13 Antibody (PACO08953)
Based on the information provided in the URL, the DUSP13 Antibody (PACO08953) is a polyclonal antibody designed for research involving Dual-Specificity Phosphatase 13 (DUSP13), a protein belonging to the DUSP family known for its role in dephosphorylating both phosphotyrosine and phosphoserine/threonine residues. The antibody is raised in rabbits and is highly reactive with human samples, making it suitable for various applications such as Western blot, immunofluorescence, and immunohistochemistry.DUSP13 is a critical regulator of signaling pathways involved in cell growth, differentiation, and inflammation.
Its dysregulation has been linked to various diseases including cancer, neurodegenerative disorders, and autoimmune conditions. By targeting DUSP13, researchers can gain insights into the mechanisms underlying these diseases and potentially develop novel therapeutic strategies.Overall, the DUSP13 Antibody (PACO08953) is a valuable tool for researchers interested in understanding the role of DUSP13 in health and disease, making it a crucial component in studies related to molecular biology, cell signaling, and therapeutic development.
| Antibody Name: | DUSP13 Antibody (PACO08953) |
| Antibody SKU: | PACO08953 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human DUSP13 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | dual specificity phosphatase 13;DUSP13;BEDP;DUSP13A;DUSP13B;FLJ32450;MDSP;SKRP4;TMDP ; |
| UniProt Protein Function: | DUSP13 iso5: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Cell cycle regulation; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 10q22.2 Molecular Function:protein binding Biological Process: meiosis; protein amino acid dephosphorylation; spermatogenesis |
| NCBI Summary: | Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6B8I1 |
| NCBI GenInfo Identifier: | 74748394 |
| NCBI Gene ID: | 51207 |
| NCBI Accession: | Q6B8I1.1 |
| UniProt Secondary Accession: | Q6B8I1,Q96J67, |
| UniProt Related Accession: | Q6B8I1,Q9UII6 |
| Molecular Weight: | 17,283 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 13 isoform A |
| NCBI Synonym Full Names: | dual specificity phosphatase 13 |
| NCBI Official Symbol: | DUSP13Â Â |
| NCBI Official Synonym Symbols: | BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13BÂ Â |
| NCBI Protein Information: | dual specificity protein phosphatase 13 |
| UniProt Protein Name: | Dual specificity protein phosphatase 13 isoform A |
| UniProt Synonym Protein Names: | Branching-enzyme interacting DSP; Muscle-restricted DSP; MDSP |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP13Â Â |
| UniProt Entry Name: | DS13A_HUMAN |
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