DUSP12 Rabbit Polyclonal Antibody (CAB13247)
- SKU:
- CAB13247
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | DUSP12 Rabbit Polyclonal Antibody |
SKU: | CAB13247 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_009171.1). |
Sequence: | LMKT DQLP FEKA YEKL QILK PEAK MNEG FEWQ LKLY QAMG YEVD TSSA IYKQ YRLQ KVTE KYPE LQNL PQEL FAVD PTTV SQGL KDEV LYKC RKCR RSLF RSSS ILDH REGS GPIA FAHK RMTP SSML TTGR QAQC TSYF I |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | YVH1; DUSP1; DUSP12 |
Positive Sample: | Jurkat,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 38kDa |
Observed MW: | 36kDa |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
Purification Method: | Affinity purification |
Gene ID: | 11266 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |