The DUSP11 Polyclonal Antibody (PAC062875) is a valuable tool for researchers studying DUSP11, a member of the dual specificity protein phosphatase family known to regulate various signaling pathways in cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.DUSP11 is involved in the dephosphorylation of phosphoserine and phosphothreonine residues on target proteins, therefore playing a role in cellular processes such as cell growth, differentiation, and stress response.
Its dysregulation has been implicated in diseases such as cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.By utilizing the DUSP11 Polyclonal Antibody, researchers can detect and analyze DUSP11 protein levels in different cell types, providing valuable insights into its functions and potential implications in disease pathology. This antibody is a reliable tool for studies in molecular biology, cell signaling, and drug development, offering new avenues for understanding and targeting DUSP11-mediated pathways.
Antibody Name:
DUSP11 Antibody (PACO62875)
Antibody SKU:
PACO62875
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human RNA/RNP complex-1-interacting phosphatase protein (105-377AA)
Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate. All lanes: DUSP11 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39, 26 kDa. Observed band size: 39 kDa.
Background:
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Synonyms:
RNA/RNP complex-1-interacting phosphatase (EC 3.1.3) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1), DUSP11, PIR1
UniProt Protein Function:
DUSP11: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.-; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 2p13.1Cellular Component: nuclear speck; nucleusMolecular Function: phosphoric monoester hydrolase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; RNA bindingBiological Process: protein amino acid dephosphorylation; RNA metabolic process; RNA processing
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
