The DUSP11 Polyclonal Antibody (PAC017396) is a high-quality research tool designed for studying DUSP11, a dual-specificity phosphatase involved in the regulation of MAP kinase signaling pathways. This antibody, produced in rabbits, specifically targets human samples and has been validated for use in Western blot applications.DUSP11 plays a key role in cellular signaling by dephosphorylating MAP kinases, thus affecting various cellular processes such as proliferation, differentiation, and apoptosis. Its dysregulation has been linked to diseases like cancer, neurodegenerative disorders, and inflammatory conditions, making it a promising target for therapeutic intervention.
By using the DUSP11 Polyclonal Antibody, researchers can accurately detect and analyze DUSP11 protein levels in different cell types, providing valuable insights into its function and potential implications in disease pathology. This versatile antibody is an essential tool for investigations in molecular biology, cell signaling, and drug discovery.
Antibody Name:
DUSP11 Antibody (PACO17396)
Antibody SKU:
PACO17396
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17396(DUSP11 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
DUSP11: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.-; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 2p13.1Cellular Component: nuclear speck; nucleusMolecular Function: phosphoric monoester hydrolase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; RNA bindingBiological Process: protein amino acid dephosphorylation; RNA metabolic process; RNA processing
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
