The DUSP1 Polyclonal Antibody (CAB2919) is a valuable tool for researchers studying the dual-specificity phosphatase 1 (DUSP1) protein. DUSP1, also known as MAP kinase phosphatase-1 (MKP-1), plays a crucial role in the regulation of cellular signaling pathways involved in inflammation, immune response, and cell proliferation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to DUSP1, researchers can detect and analyze the protein in various cell types, making it ideal for studies in immunology, cancer research, and the development of therapeutics targeting DUSP1.
Understanding the function and regulation of DUSP1 is critical for developing novel treatments for inflammatory diseases, cancer, and other conditions where dysregulation of signaling pathways plays a role. The DUSP1 Polyclonal Antibody provides a reliable tool for investigating the role of DUSP1 in various physiological and pathological processes, ultimately leading to the development of targeted therapies.
Product Name:
DUSP1/MKP1 Rabbit Polyclonal Antibody
SKU:
CAB2919
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human DUSP1/MKP1 (NP_004408.1).
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Purification Method:
Affinity purification
Gene ID:
1843
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using DUSP1/MKP1 antibody (CAB2919) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
