The DUSP1/MKP1 Monoclonal Antibody is a valuable tool for researchers studying the DUSP1 protein, also known as MAP kinase phosphatase 1, which plays a key role in regulating cellular response to stress and inflammation. This antibody, produced using hybridoma technology, specifically targets the DUSP1 protein in human samples and is validated for use in various applications, including Western blotting and immunofluorescence.DUSP1 is a critical regulator of MAP kinase signaling pathways, which are involved in a wide range of cellular processes, including cell growth, differentiation, and apoptosis.
Dysregulation of these pathways is implicated in various diseases, such as cancer, inflammatory disorders, and neurodegenerative conditions. By targeting DUSP1, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the DUSP1/MKP1 Monoclonal Antibody is a valuable tool for researchers interested in studying the role of DUSP1 in health and disease, with potential applications in a wide range of fields, including cancer biology, immunology, and drug development.
Product Name:
DUSP1/MKP1 Monoclonal Antibody
SKU:
CAB22201
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DUSP1/MKP1 (NP_004408.1).
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Purification Method:
Affinity purification
Gene ID:
1843
Clone Number:
ARC56245
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of HepG2, using DUSP1/MKP1 antibody (CAB22201) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
