The DUS2 Polyclonal Antibody (PACO04663) is a valuable tool for researchers studying the DUS2 protein, which plays a crucial role in RNA processing and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the DUS2 protein, it allows for the effective detection and analysis of this important molecule in various cell types.DUS2, also known as Dihydrouridine synthase 2, is involved in the modification of tRNA molecules, impacting translation efficiency and fidelity. Dysregulation of DUS2 has been linked to various diseases, including cancer and neurological disorders.
By studying the function of DUS2, researchers can gain insights into its role in disease pathogenesis and potentially identify novel therapeutic targets.This antibody is a valuable tool for investigators in the fields of molecular biology, genetics, and biochemistry, providing a means to explore the function and regulation of the DUS2 protein in different biological contexts. Its specificity and sensitivity make it ideal for studies aimed at elucidating the mechanisms underlying RNA modification and its implications for human health.
Antibody Name:
DUS2 Antibody
Antibody SKU:
PACO04663
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human DUS2L.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
DUS2L; DUS2; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2
UniProt Protein Function:
DUS2L: Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Belongs to the dus family. Dus2 subfamily.Protein type: EC 1.3.1.-; EC 1.-.-.-; RNA-binding; OxidoreductaseChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; cytosolMolecular Function: double-stranded RNA binding; protein binding; protein kinase inhibitor activity; tRNA dihydrouridine synthase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
