DUOX1 Rabbit Polyclonal Antibody (CAB8583)
- SKU:
- CAB8583
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | DUOX1 Rabbit Polyclonal Antibody |
SKU: | CAB8583 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1312-1551 of human DUOX1 (NP_059130.2). |
Sequence: | ALGT TEYH PFTL TSAP HEDT LSLH IRAA GPWT TRLR EIYS APTG DRCA RYPK LYLD GPFG EGHQ EWHK FEVS VLVG GGIG VTPF ASIL KDLV FKSS VSCQ VFCK KIYF IWVT RTQR QFEW LADI IREV EEND HQDL VSVH IYIT QLAE KFDL RTTM LYIC ERHF QKVL NRSL FTGL RSIT HFGR PPFE PFFN SLQE VHPQ VRKI GVFS CGPP GMTK NVEK ACQL INRQ DRTH FSHH YENF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LNOX1; THOX1; NOXEF1; DUOX1 |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Apical cell membrane, Multi-pass membrane protein. |
Calculated MW: | 177kDa |
Observed MW: | 180kDa |
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 53905 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |