UniProt Protein Function: | DTX4: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11q12.1Cellular Component: cytosolMolecular Function: zinc ion binding; ligase activityBiological Process: regulation of interferon type I production; Notch signaling pathway; positive regulation of interferon type I production; protein ubiquitination; innate immune response |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9Y2E6 |
NCBI GenInfo Identifier: | 148237498 |
NCBI Gene ID: | 23220 |
NCBI Accession: | NP_055992.1 |
UniProt Secondary Accession: | Q9Y2E6,Q0VF38 |
UniProt Related Accession: | Q9Y2E6 |
Molecular Weight: | 67,258 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase DTX4 isoform 1 |
NCBI Synonym Full Names: | deltex 4, E3 ubiquitin ligase |
NCBI Official Symbol: | DTX4Â Â |
NCBI Official Synonym Symbols: | RNF155Â Â |
NCBI Protein Information: | E3 ubiquitin-protein ligase DTX4; deltex4; deltex 4 homolog; deltex homolog 4; protein deltex-4; RING finger protein 155 |
UniProt Protein Name: | E3 ubiquitin-protein ligase DTX4 |
UniProt Synonym Protein Names: | Protein deltex-4; Deltex4; RING finger protein 155 |
Protein Family: | Protein DETOXIFICATION |
UniProt Gene Name: | DTX4Â Â |
UniProt Entry Name: | DTX4_HUMAN |