The DTX3 Polyclonal Antibody (PACO14337) is a valuable tool for researchers studying the DTX3 protein, a key player in the Notch signaling pathway. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it an ideal choice for Western blot applications. By binding to the DTX3 protein, this antibody enables the detection and analysis of DTX3 expression in various cell types.DTX3, also known as deltex E3 ubiquitin ligase 3, is involved in the regulation of Notch signaling, a critical pathway that controls cell fate determination and development. Dysregulation of the Notch pathway, including DTX3 expression, has been linked to various diseases, including cancer and developmental disorders.
By studying the role of DTX3 in Notch signaling, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic targets.Overall, the DTX3 Polyclonal Antibody (PACO14337) is a powerful tool for investigating the function of the DTX3 protein in various biological processes and disease contexts. Its high specificity and reactivity with human samples make it an essential reagent for researchers interested in unraveling the complexities of the Notch signaling pathway.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: SKOV3 cells, Primary antibody: PACO14337(DTX3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14337(DTX3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
DTX3 functions as an E3 ubiquitin ligase. It is regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms:
deltex homolog 3 (Drosophila)
UniProt Protein Function:
DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-Chromosomal Location of Human Ortholog: 12q13.3Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
