DTX1 Antibody (PACO19562)
- SKU:
- PACO19562
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
DTX1 Antibody (PACO19562)
The DTX1 Antibody (PAC019562) is a polyclonal antibody designed for research involving DTX1, a protein involved in Notch signaling pathway regulation. The antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to the DTX1 protein, this antibody enables reliable detection and analysis in various cell types, allowing for in-depth studies in cell signaling and cancer research.DTX1, a ubiquitin ligase, is a key player in the regulation of Notch signaling, a crucial pathway involved in various cellular processes such as development, differentiation, and proliferation.
Dysregulation of the Notch pathway, including altered DTX1 activity, has been implicated in numerous diseases, including cancer and developmental disorders. Therefore, understanding the role of DTX1 in Notch signaling is essential for developing targeted therapies for these conditions.With its high specificity and sensitivity, the DTX1 Antibody (PAC019562) is a valuable tool for researchers aiming to investigate the function and regulation of DTX1 in different biological contexts. By providing accurate and reliable data, this antibody contributes to advancing our understanding of Notch signaling and its implications in health and disease.
| Antibody Name: | DTX1 Antibody (PACO19562) |
| Antibody SKU: | PACO19562 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human DTX1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19562(DTX1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19562(DTX1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. |
| Synonyms: | deltex homolog 1 (Drosophila) |
| UniProt Protein Function: | DTX1: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. Belongs to the Deltex family. |
| UniProt Protein Details: | Protein type:Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 12q24.13 Cellular Component: cytoplasm; cytosol Molecular Function:Notch binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding Biological Process: cell surface receptor linked signal transduction; negative regulation of neuron differentiation; Notch signaling pathway; regulation of Notch signaling pathway; transcription from RNA polymerase II promoter |
| NCBI Summary: | Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86Y01 |
| NCBI GenInfo Identifier: | 37077046 |
| NCBI Gene ID: | 1840 |
| NCBI Accession: | Q86Y01.1 |
| UniProt Secondary Accession: | Q86Y01,O60630, Q9BS04, |
| UniProt Related Accession: | Q86Y01 |
| Molecular Weight: | 67,368 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase DTX1 |
| NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 1 |
| NCBI Official Symbol: | DTX1Â Â |
| NCBI Official Synonym Symbols: | hDx-1Â Â |
| NCBI Protein Information: | E3 ubiquitin-protein ligase DTX1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase DTX1 |
| UniProt Synonym Protein Names: | Protein deltex-1; Deltex1; hDTX1 |
| Protein Family: | Protein DETOXIFICATION |
| UniProt Gene Name: | DTX1Â Â |
| UniProt Entry Name: | DTX1_HUMAN |
Related Products
DTX1 Antibody (PACO55202)
DTX1 Antibody (PACO19561)
DTX1 Antibody (PACO17788)
DTX1 Rabbit Polyclonal Antibody (CAB20499)
Human DTX1 / Deltex1 ELISA Kit
Mouse Protein deltex-1 (Dtx1) ELISA Kit (MOEB2116)
Human Protein deltex-1 (DTX1) ELISA Kit (HUEB2366)
