The DTNBP1 Polyclonal Antibody (CAB16581) is a valuable research tool for studying DTNBP1, a protein involved in neurotransmission and synaptic vesicle trafficking. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in various applications including Western blot and immunofluorescence.DTNBP1, also known as dysbindin-1, is a key player in the regulation of neurotransmitter release and synaptic function, making it a target of interest in neurobiology and neuropsychiatric research. Dysregulation of DTNBP1 has been implicated in conditions such as schizophrenia, bipolar disorder, and autism spectrum disorders, highlighting the importance of studying its function and mechanisms of action.
The DTNBP1 Polyclonal Antibody enables researchers to detect and analyze DTNBP1 protein expression in different cell types and tissues, providing valuable insights into its role in normal and disease states. By understanding the function of DTNBP1, researchers may uncover new therapeutic targets and treatment strategies for neuropsychiatric disorders.
Product Name:
DTNBP1 Rabbit Polyclonal Antibody
SKU:
CAB16581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human DTNBP1 (NP_115498.2).
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
84062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human placenta using DTNBP1 Rabbit pAb (CAB16581) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
