The DSCC1 Polyclonal Antibody (PAC042110) is a vital tool for researchers studying DSCC1, a protein involved in DNA replication and cell cycle regulation. This antibody, produced using rabbits, demonstrates high reactivity with human samples and has been specifically validated for use in Western blot applications. By targeting the DSCC1 protein, the antibody enables precise detection and analysis in a variety of cell types, making it an essential resource for investigations in molecular biology and cancer research.DSCC1 is known for its crucial role in DNA replication as a component of the DSCC1-Sld3-GINS (DSG) complex, which is essential for the initiation and elongation stages of DNA replication.
Dysregulation of DSCC1 has been linked to genomic instability and tumorigenesis, highlighting its significance in cancer biology and therapeutic targeting. By unraveling the functions of DSCC1, researchers can gain insights into the mechanisms driving cancer progression and potentially identify novel therapeutic approaches.In summary, the DSCC1 Polyclonal Antibody (PAC042110) provides a reliable tool for investigating the functions of DSCC1 in cellular processes such as DNA replication and cell cycle control. Its high specificity and sensitivity make it suitable for a range of research applications, offering valuable insights into the role of DSCC1 in cancer development and progression.
Antibody Name:
DSCC1 Antibody (PACO42110)
Antibody SKU:
PACO42110
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Sister chromatid cohesion protein DCC1 protein (1-393AA)
Western blot. All lanes: DSCC1 antibody at 8µg/ml + CEM whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Background:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.
Synonyms:
Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog), DSCC1, DCC1
UniProt Protein Function:
DCC1: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. Belongs to the DCC1 family.Chromosomal Location of Human Ortholog: 8q24.12Cellular Component: chromatin; chromosome, pericentric region; nucleoplasmMolecular Function: DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activityBiological Process: maintenance of mitotic sister chromatid cohesion; regulation of DNA replication
UniProt Protein Details:
NCBI Summary:
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
