DSCAM Antibody (PACO57736)
- SKU:
- PACO57736
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
DSCAM Antibody (PACO57736)
The DSCAM Polyclonal Antibody (PACO57736) is a valuable tool for researchers studying Down Syndrome Cell Adhesion Molecule (DSCAM). This cell surface protein plays a crucial role in neuronal development and has been implicated in various neurological disorders.Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the DSCAM protein, researchers can detect and analyze its expression in different cell types, facilitating studies in neurobiology and developmental biology.
The role of DSCAM in neuronal connectivity and synaptic plasticity makes it a key target for investigations into conditions such as autism, intellectual disabilities, and neurodevelopmental disorders. Understanding the function and regulation of DSCAM could provide valuable insights into the underlying mechanisms of these disorders and potentially lead to the development of new therapeutic strategies.
| Antibody Name: | DSCAM Antibody (PACO57736) |
| Antibody SKU: | PACO57736 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Down syndrome cell adhesion molecule protein (1711-1867AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO57736 diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57736 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). |
| Synonyms: | Down syndrome cell adhesion molecule (CHD2), DSCAM |
| UniProt Protein Function: | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | O60469 |
| NCBI GenInfo Identifier: | 20127422 |
| NCBI Gene ID: | 1826 |
| NCBI Accession: | NP_001380.2 |
| UniProt Secondary Accession: | O60469,O60468 |
| UniProt Related Accession: | O60469 |
| Molecular Weight: | 173,804 Da |
| NCBI Full Name: | Down syndrome cell adhesion molecule isoform CHD2-42 |
| NCBI Synonym Full Names: | DS cell adhesion molecule |
| NCBI Official Symbol: | DSCAMÂ Â |
| NCBI Official Synonym Symbols: | CHD2; CHD2-42; CHD2-52Â Â |
| NCBI Protein Information: | Down syndrome cell adhesion molecule |
| UniProt Protein Name: | Down syndrome cell adhesion molecule |
| UniProt Synonym Protein Names: | CHD2 |
| Protein Family: | Down syndrome cell adhesion molecule |
| UniProt Gene Name: | DSCAMÂ Â |
| UniProt Entry Name: |
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