The DRP1 Polyclonal Antibody is a valuable tool for researchers studying DRP1, a protein involved in mitochondrial dynamics and cell division. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the DRP1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and neurodegenerative diseases.DRP1, also known as dynamin-related protein 1, plays a key role in regulating mitochondrial fission and fusion, which are essential processes for maintaining cellular health and function. Dysregulation of DRP1 has been linked to various pathological conditions, including neurodegenerative disorders like Parkinson's disease and Alzheimer's disease.
By studying the function of DRP1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.Overall, the DRP1 Polyclonal Antibody is a valuable tool for investigating the role of DRP1 in mitochondrial dynamics and its implications for cellular health and disease. Researchers interested in exploring the functions of DRP1 in different cellular contexts will find this antibody to be an essential resource for their studies.
Product Name:
DRP1 Polyclonal Antibody
SKU:
CAB21310
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human DRP1. (NP_036192.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using DRP1 antibody (CAB21310) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
