DROSHA Rabbit Monoclonal Antibody (CAB19598)
- SKU:
- CAB19598
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DROSHA Rabbit Monoclonal Antibody |
SKU: | CAB19598 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DROSHA (Q9NRR4). |
Sequence: | MMQG NTCH RMSF HPGR GCPR GRGG HGAR PSAP SFRP QNLR LLHP QQPP VQYQ YEPP SAPS TTFS NSPA PNFL PPRP DFVP FPPP MPPS AQGP LPPC PIRP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976; DROSHA |
Positive Sample: | 293T,HeLa,Jurkat,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus. |
Calculated MW: | 159kDa |
Observed MW: | 159kDa |
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
Purification Method: | Affinity purification |
Gene ID: | 29102 |
Clone Number: | ARC0077 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |