The Drebrin Polyclonal Antibody (CAB6366) is a valuable tool for researchers studying Drebrin, a key protein involved in neuronal development and synaptic plasticity. This antibody, raised in rabbits, is highly specific for human Drebrin and has been validated for use in Western blot applications. By binding to Drebrin, this antibody allows for the detection and analysis of Drebrin expression in various cell types, making it ideal for studies in neuroscience and neurodegenerative diseases.Drebrin is essential for the formation and maintenance of dendritic spines, the small protrusions on neurons where synaptic connections occur.
Dysregulation of Drebrin has been implicated in conditions such as Alzheimer's disease and schizophrenia, highlighting its importance in neural function and synaptic plasticity. By investigating Drebrin expression and function using this antibody, researchers can gain insights into the mechanisms underlying these neurological disorders and potentially identify new therapeutic targets.
Product Name:
DBN1 Rabbit Polyclonal Antibody
SKU:
CAB6366
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-649 of human DBN1 (NP_004386.2).
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1627
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DBN1 antibody (CAB6366) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
