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Anti-DRD4 Antibody (CAB1337)

SKU:
CAB1337
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 3 Anti-DRD4 Antibody CAB1337
  • Cell Biology Antibodies 3 Anti-DRD4 Antibody CAB1337
€139 - €419
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Description

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Antibody Name:Anti-DRD4 Antibody
Antibody SKU:CAB1337
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_000788.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_000788.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AWLL SPRL CDAL MAMD VMLC TASI FNLC AISV DRFV AVAV PLRY NRQG GSRR QLLL IGAT WLLS AAVA APVL CGLN DVRG RDPA VCRL EDRD YVVY SSVC S
Gene ID:1815
Uniprot:P21917
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:48kDa
Observed MW:52kDa
Synonyms:DRD4, D4DR
Background:This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
UniProt Protein Function:DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; protein binding; SH3 domain binding

Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; response to amphetamine; synaptic transmission, dopaminergic

Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait

NCBI Summary:This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
UniProt Code:P21917
NCBI GenInfo Identifier:1345939
NCBI Gene ID:1815
NCBI Accession:P21917.2
UniProt Secondary Accession:P21917,Q7Z7Q5, Q8NGM5, B0M0J7,
UniProt Related Accession:P21917
Molecular Weight:48,361 Da
NCBI Full Name:D(4) dopamine receptor
NCBI Synonym Full Names:dopamine receptor D4
NCBI Official Symbol:DRD4  
NCBI Official Synonym Symbols:D4DR  
NCBI Protein Information:D(4) dopamine receptor
UniProt Protein Name:D(4) dopamine receptor
UniProt Synonym Protein Names:D(2C) dopamine receptor; Dopamine D4 receptor
Protein Family:D(4) dopamine receptor
UniProt Gene Name:DRD4  
UniProt Entry Name:DRD4_HUMAN
Anti-DRD4 Antibody (CAB1337)Western blot analysis of extracts of various cell lines, using DRD4 antibody (CAB1337) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-DRD4 Antibody (CAB1337)Immunohistochemistry of paraffin-embedded rat retina using DRD4 antibody (CAB1337) at dilution of 1:100 (40x lens).

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