The DRD3 Polyclonal Antibody (CAB14622) is specifically designed for research involving the dopamine D3 receptor (DRD3), a G-protein coupled receptor involved in the regulation of neurotransmitters. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DRD3 protein, this antibody enables the detection and analysis of DRD3 in various cell types, making it an ideal tool for studying the role of DRD3 in neurological disorders and psychiatric conditions.
The DRD3 receptor is known to play a crucial role in the modulation of dopamine signaling, which is implicated in numerous neurological disorders, including Parkinson's disease, schizophrenia, and addiction. Understanding the function and regulation of DRD3 is essential for developing targeted therapies for these conditions, making the DRD3 Polyclonal Antibody a valuable asset for researchers in the field of neuroscience and pharmacology.
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
Purification Method:
Affinity purification
Gene ID:
1814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Dopamine Receptor D3 (DRD3) Rabbit pAb (CAB14622) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
