The DRAP1 Polyclonal Antibody (CAB17616) is a valuable tool for researchers studying DRAP1, a protein involved in immune regulation and cell survival pathways. This antibody, generated in rabbits, is highly specific to DRAP1 in human samples and has been validated for use in Western blot applications. By binding to DRAP1, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.DRAP1, also known as DNA damage-regulated autophagy modulator protein 1, plays a crucial role in maintaining cellular homeostasis by regulating autophagy, a process that removes damaged organelles and proteins to prevent cell damage and promote survival.
Dysregulation of DRAP1 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.By investigating the function of DRAP1 using this polyclonal antibody, researchers can gain valuable insights into the mechanisms that govern cell survival and death, offering new avenues for developing treatments for diseases characterized by dysregulated autophagy. This antibody is a valuable tool for advancing our understanding of DRAP1 biology and its implications for human health.
Product Name:
DRAP1 Rabbit Polyclonal Antibody
SKU:
CAB17616
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2).
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Purification Method:
Affinity purification
Gene ID:
10589
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DRAP1 Rabbit pAb (CAB17616) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
