The DRAM1 Polyclonal Antibody (CAB15468) is a valuable tool for researchers studying DRAM1, a key regulator of autophagy and cell death. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DRAM1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in cell biology and cancer research.DRAM1, also known as Damage-Regulated autophagy modulator 1, is crucial for the induction of autophagy and the regulation of apoptosis, making it a significant player in maintaining cellular homeostasis.
Its role in promoting cell survival under stress conditions and triggering programmed cell death emphasizes its importance in understanding various diseases, including cancer and neurodegenerative disorders. By elucidating the mechanisms of DRAM1, researchers can uncover new therapeutic targets for the treatment of these conditions.
Product Name:
DRAM1 Rabbit Polyclonal Antibody
SKU:
CAB15468
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRAM1 (NP_060840.2).
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
Purification Method:
Affinity purification
Gene ID:
55332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DRAM1 Rabbit pAb (CAB15468) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
