The DR5 Rabbit Monoclonal Antibody (CAB19043) is a powerful tool for research involving DR5, a cell surface receptor known for its role in regulating cell death pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting and immunohistochemistry applications.DR5, also known as TNFRSF10B, is a member of the tumor necrosis factor receptor superfamily and is involved in apoptosis, particularly in response to treatment with certain chemotherapeutic drugs.
Its importance in cell death pathways makes it a key target for research in cancer biology and therapy development.By targeting the DR5 protein, researchers can gain valuable insights into the mechanisms of cell death and potentially uncover new therapeutic strategies for treating cancer. The DR5 Rabbit Monoclonal Antibody offers researchers a reliable tool for studying DR5 expression and function in various cell types, making it an essential reagent for studies in oncology and cell biology.
Product Name:
DR5/TRAILR2/TNFRSF10B Rabbit Monoclonal Antibody
SKU:
CAB19043
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 341-440 of human DR5/TRAILR2/TNFRSF10B (O14763).
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8795
Clone Number:
ARC0406
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using DR5/TRAILR2/TNFRSF10B Rabbit mAb (CAB19043) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
