The DR1 Polyclonal Antibody (CAB13298) is a vital tool for researchers studying the DR1 protein, a cell surface molecule involved in immune regulation and antigen presentation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the DR1 protein, researchers can effectively detect and analyze its expression in various cell types, making it an essential reagent for immunology and cancer research studies.The DR1 protein, also known as HLA-DR alpha chain, plays a crucial role in the immune response by presenting antigens to T cells and initiating adaptive immune responses.
Its involvement in antigen presentation makes it a key player in the development of immune therapies, vaccines, and treatments for infectious diseases and autoimmune disorders. Understanding the function and expression of DR1 is essential for unraveling the complexities of the immune system and exploring novel therapeutic targets for various immunological conditions.
Product Name:
DR1 Rabbit Polyclonal Antibody
SKU:
CAB13298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1).
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Purification Method:
Affinity purification
Gene ID:
1810
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse spleen, using DR1 Rabbit pAb (CAB13298) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
