The DPY19L1 Polyclonal Antibody (PAC058076) is a valuable tool for researchers studying DPY19L1, a protein involved in spermatogenesis and male fertility. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DPY19L1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in reproductive biology and male infertility.DPY19L1 is essential for the correct formation of the acrosome, a structure on the head of sperm cells that is crucial for fertilization.
Mutations in the DPY19L1 gene have been associated with male infertility, making it an important target for research aimed at understanding and treating reproductive disorders. By studying DPY19L1 and its role in spermatogenesis, researchers may uncover new insights into the causes of infertility and develop innovative therapies to address this common health concern.
Antibody Name:
DPY19L1 Antibody (PACO58076)
Antibody SKU:
PACO58076
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Probable C-mannosyltransferase DPY19L1 protein (513-665AA)
Immunofluorescence staining of A549 cells with PACO58076 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
DPY19L1: Belongs to the dpy-19 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7p14.3-p14.2Cellular Component: membrane; nuclear inner membraneMolecular Function: mannosyltransferase activityBiological Process: protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
