The DPS Antibody (PACO52138) is a highly specific and sensitive tool for researchers studying the role of DPS in various biological processes. DPS, also known as DNA polymerase sigma, is a key enzyme involved in DNA replication and repair, making it essential for maintaining genomic stability.This polyclonal antibody, produced in rabbits, is optimized for detection of DPS in human samples and has been validated for use in Western blot applications. Its high reactivity and specificity make it a reliable tool for studying the expression and function of DPS in different cell types and tissues.
With its ability to specifically bind to DPS, this antibody enables accurate detection and analysis of DPS levels, providing valuable insights into its role in DNA replication, repair, and other cellular processes. It is a valuable resource for researchers investigating the mechanisms underlying genomic stability and the potential implications of DPS dysregulation in diseases such as cancer and genetic disorders.
Antibody Name:
dps Antibody (PACO52138)
Antibody SKU:
PACO52138
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Mycobacterium smegmatis
Immunogen:
Recombinant Mycobacterium smegmatis DNA protection during starvation protein (1-183AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: dps antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa.
Background:
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage.
Synonyms:
DNA protection during starvation protein (EC 1.16), dps
UniProt Protein Function:
Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction (). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage.
