The DPPA4 Polyclonal Antibody (CAB13724) is a valuable tool for researchers studying DPPA4, a key protein involved in pluripotency and early embryonic development. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in various applications, including Western blotting and immunohistochemistry.DPPA4, also known as developmental pluripotency associated 4, is essential for maintaining pluripotent stem cells and plays a crucial role in regulating gene expression during early embryogenesis. By targeting DPPA4 with this antibody, researchers can detect and analyze the protein in different cell types, providing valuable insights into its function and potential therapeutic applications.
With its high reactivity and specificity, the DPPA4 Polyclonal Antibody (CAB13724) is an excellent choice for scientists investigating stem cell biology, developmental biology, and regenerative medicine. By elucidating the role of DPPA4 in cellular processes, researchers can advance our understanding of embryonic development and potentially uncover new targets for treating a range of diseases and disorders.
Product Name:
DPPA4 Rabbit Polyclonal Antibody
SKU:
CAB13724
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 15-304 of human DPPA4 (NP_060659.3).
This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55211
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DPPA4 Rabbit pAb (CAB13724) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
