The DPP6 Polyclonal Antibody (CAB10210) is a valuable tool for researchers studying DPP6, a member of the dipeptidyl-peptidase (DPP) family of proteins involved in regulating cellular processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications, enabling precise detection and analysis of DPP6 protein levels in various cell types.DPP6 is known to play a role in diverse biological functions, including synaptic plasticity, neuronal excitability, and ion channel regulation.
Dysregulation of DPP6 has been linked to neurological disorders such as epilepsy and schizophrenia, making it a promising target for therapeutic intervention. By utilizing the DPP6 Polyclonal Antibody, researchers can further investigate the function and role of DPP6 in both normal physiological processes and disease states, potentially leading to new insights and treatment strategies in neurobiology and neurology research.
Product Name:
DPP6 Rabbit Polyclonal Antibody
SKU:
CAB10210
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 117-210 of human DPP6 (NP_001277182.1).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
98kDa
Observed MW:
105kDa
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using DPP6 antibody (CAB10210) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
