DPM1 Rabbit Polyclonal Antibody (CAB7757)
- SKU:
- CAB7757
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | DPM1 Rabbit Polyclonal Antibody |
SKU: | CAB7757 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1). |
Sequence: | MASL EVSR SPRR SRRE LEVR SPRQ NKYS VLLP TYNE RENL PLIV WLLV KSFS ESGI NYEI IIID DGSP DGTR DVAE QLEK IYGS DRIL LRPR EKKL GLGT AYIH GMKH ATGN YIII MDAD LSHH PKFI PEFI RKQK EGNF DIVS GTRY KGNG GVYG WDLK RKII SRGA NFLT QILL RPGA SDLT GSFR LYRK EVLE KLIE KCVS KGYV FQME MIVR ARQL NYTI GEVP ISFV DRVY GESK LGGN EIVS FLKG LLTL FATT |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | MPDS; CDGIE; DPM1 |
Positive Sample: | NCI-H460,HeLa,SKOV3,Mouse pancreas,Mouse liver,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum. |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8813 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |