UniProt Protein Function: | DPH5: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. Belongs to the diphthine synthase family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Methyltransferase; EC 2.1.1.98Chromosomal Location of Human Ortholog: 1p21.2Cellular Component: cytosolMolecular Function: diphthine synthase activityBiological Process: methylation; cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; post-translational protein modification |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H2P9 |
NCBI GenInfo Identifier: | 117190326 |
NCBI Gene ID: | 51611 |
NCBI Accession: | NP_001070862.1 |
UniProt Secondary Accession: | Q9H2P9 |
UniProt Related Accession: | Q9H2P9 |
Molecular Weight: | 25 kDa |
NCBI Full Name: | diphthine methyl ester synthase isoform a |
NCBI Synonym Full Names: | diphthamide biosynthesis 5 |
NCBI Official Symbol: | DPH5Â Â |
NCBI Official Synonym Symbols: | AD-018; CGI-30; NPD015; HSPC143Â Â |
NCBI Protein Information: | diphthine methyl ester synthase |
UniProt Protein Name: | Diphthine synthase |
UniProt Synonym Protein Names: | Diphthamide biosynthesis methyltransferase |
Protein Family: | Diphthine methyl ester synthase |
UniProt Gene Name: | DPH5Â Â |
UniProt Entry Name: | DPH5_HUMAN |