UniProt Protein Function: | DPH3: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Belongs to the DPH3 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p25.1Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: protein binding; metal ion bindingBiological Process: negative regulation of protein secretion; cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of binding; post-translational protein modification |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] |
UniProt Code: | Q96FX2 |
NCBI GenInfo Identifier: | 114145654 |
NCBI Gene ID: | 285381 |
NCBI Accession: | NP_001040899.1 |
UniProt Secondary Accession: | Q96FX2 |
UniProt Related Accession: | Q96FX2 |
Molecular Weight: | 9,240 Da |
NCBI Full Name: | DPH3 homolog isoform 2 |
NCBI Synonym Full Names: | diphthamide biosynthesis 3 |
NCBI Official Symbol: | DPH3Â Â |
NCBI Official Synonym Symbols: | DESR1; DPH3A; KTI11; ZCSL2; DELGIP; DELGIP1Â Â |
NCBI Protein Information: | DPH3 homolog; DPH3, KTI11 homolog; DPH3A, KTI11 homolog A; Del-GEF interacting protein; delGEF-interacting protein 1; zinc finger, CSL-type containing 2; DPH3 homolog (KTI11, S. cerevisiae); zinc finger, CSL domain containing 2; CSL-type zinc finger-containing protein 2; diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1; deafness locus putative guanine nucleotide exchange factor interacting protein 1 |
UniProt Protein Name: | DPH3 homolog |
UniProt Synonym Protein Names: | CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1 |
Protein Family: | Diphthamide biosynthesis protein |
UniProt Gene Name: | DPH3Â Â |
UniProt Entry Name: | DPH3_HUMAN |